Pubmed- Inflammatory Bowel Disease: A Gastrointestinal Presentation of Congenital Plasminogen Deficiency - IBD Reporter Newsfeed - IBD Support Group Forums - IBDsupport.org

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Pubmed- Inflammatory Bowel Disease: A Gastrointestinal Presentation of Congenital Plasminogen Deficiency


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Posted 07 June 2021 - 01:48 PM

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ACG Case Rep J. 2021 Jun 2;8(5):e00613. doi: 10.14309/crj.0000000000000613. eCollection 2021 May.

ABSTRACT

Plasminogen deficiency (PD) is a rare autosomal recessive disease that results in the formation of fibrin-rich pseudomembranes, which impair wound-healing capacity. We report a 21-year-old man with congenital PD-associated inflammatory bowel disease. After an episode of Clostridioides difficile infection, he developed chronic diarrhea. Colonoscopy revealed moderate friability and erythema of the colon. Histology showed fibrin deposits in the lamina propria of the colonic mucosa with surrounding inflammation and focal ulceration. He was treated with infliximab and achieved clinical remission. To our knowledge, this is the first reported case of colonic involvement of PD.

PMID:34095331 | PMC:PMC8174548 | DOI:10.14309/crj.0000000000000613


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