Pubmed- Mucosal IL-10 and IL-10 receptor expression patterns in paediatric patients with ulcerative colitis. - IBD Reporter Newsfeed - IBD Support Group Forums - IBDsupport.org

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Pubmed- Mucosal IL-10 and IL-10 receptor expression patterns in paediatric patients with ulcerative colitis.


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Posted 08 January 2021 - 01:36 AM

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Mucosal IL-10 and IL-10 receptor expression patterns in paediatric patients with ulcerative colitis.

Int J Exp Pathol. 2021 Jan 06;:

Authors: Wittmann Dayagi T, Werner L, Pinsker M, Salamon N, Barschak I, Weiss B, Shouval DS

Abstract
Interleukin-10 (IL-10) is a key anti-inflammatory cytokine. We aimed to assess IL-10 and IL-10 receptor (IL-10R) expression in the gut, and determine whether these patterns are altered in patients with ulcerative colitis (UC). Formalin-fixed paraffin-embedded rectal and transverse colon sections were collected from three groups of patients: (a) control subjects with normal colonoscopy and without history of inflammatory bowel disease; (b) UC patients with extensive colitis or pancolitis (E3/E4 phenotype); and © UC patients with limited distal disease (E1/E2 phenotype; n = 8-10 subjects per group). Immunohistochemistry (IHC) was performed to assess expression patterns of IL-10, IL-10R1 and IL-10R2, and was correlated with clinical, endoscopic and histologic severity indices among patients. A trend towards increased IL-10 expression was noted in rectal biopsies of patients with active UC, compared with controls. Moreover, IL-10 levels were significantly increased in transverse colon biopsies of patients with extensive/pancolitis, compared with control subjects and patients with limited distal disease. Rectal IL-10R1 and IL-10R2 levels were comparable between control subject and patients with active UC. However, transverse colon IL-10R1 levels were significantly higher in patients with E3/E4 colitis, compared with controls. Finally, we found no correlation between clinical, endoscopic and histologic severity of inflammation among UC patients and IL-10, IL-10R1 or IL-10R2 expression in rectal sections. Mucosal expression patterns of IL-10 and IL-10R, evaluated by IHC, were overall similar between control subjects and patients with active UC. Given IL-10's anti-inflammatory properties, additional studies are required to determine whether signalling through the IL-10R is altered among these patients.

PMID: 33405352 [PubMed - as supplied by publisher]



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