Endocannabinoids Attenuate the Virulence of Certain Enteropathogenic Bacteria.
Trends Microbiol. 2020 Dec 30;:
Authors: Osman M, Papon N, Weill FX
The mammalian endocannabinoid system modulates gastrointestinal physiology and immunity via lipid hormones (endocannabinoids). Ellermann et al. have recently revealed the effect of the endocannabinoid, 2-arachidonoyl glycerol (2-AG) on intestinal infection. They show that 2-AG directly modulates bacterial function by antagonizing the provirulence receptor QseC, thereby protecting mice against enteric infection. The endocannabinoid system has already been identified as a promising target in the treatment of inflammatory bowel diseases, but these new findings raise questions about the possible benefits of using cannabinoids to treat intestinal bacterial infections.
PMID: 33388214 [PubMed - as supplied by publisher]
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