Pubmed- PPARγ: A turning point for irritable bowel syndrome treatment. - IBD Reporter Newsfeed - IBD Support Group Forums -


Jump to content

- - - - -

Pubmed- PPARγ: A turning point for irritable bowel syndrome treatment.

  • Please log in to reply
No replies to this topic

#1 Health Reporter

Health Reporter


  • RSS
  • PipPipPipPip
  • 20366 posts
  • Country:United States

Posted 20 July 2020 - 01:35 AM

Related Articles

PPARγ: A turning point for irritable bowel syndrome treatment.

Life Sci. 2020 Jul 15;:118103

Authors: Roudsari NM, Lashgari NA, Zandi N, Pazoki B, Momtaz S, Sahebkar A, Abdolghaffari AH

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal (GI) disorder with negative impacts on quality of life of patients. Although the etiology of the disease is still unclear, there are a set of mechanisms and factors involved in IBS pathogenesis. Visceral hypersensitivity, impaired gut barrier, along with minor inflammation and oxidative stress are the most important triggers for IBS induction. Activation of peroxisome proliferator activated receptor-γ (PPAR-γ) has been shown to improve gut barrier, downregulate pro-inflammatory cytokines, reduce free radical production through antioxidative mechanisms, and exert anti-nociceptive effects against somatic pain. An electronic search in PubMed, Google Scholar, Scopus, and Cochrane library was performed and relevant clinical, in vivo and in vitro articles published between 2004 and June 2020 were collected. Search terms included "Irritable Bowel Syndrome" OR "IBS" OR "visceral hypersensitivity" OR "motility dysfunction" AND "peroxisome proliferator activated receptors" OR "PPAR". Herein, the efficacy of PPARγ signaling as a potential target for IBS treatment is reviewed.

PMID: 32681913 [PubMed - as supplied by publisher]

View the full article


© Copyright 1995-2014 IBD Support All rights reserved.

About Us | Contact Us | Advertise With Us | Disclaimer | Terms of Service | Crisis Resources

This website is certified by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here