Pubmed- In Silico Evaluation of Putative S100B Interacting Proteins in Healthy and IBD Gut Microbiota. - IBD Reporter Newsfeed - IBD Support Group Forums - IBDsupport.org

Advertisement

Jump to content


Photo
- - - - -

Pubmed- In Silico Evaluation of Putative S100B Interacting Proteins in Healthy and IBD Gut Microbiota.


  • Please log in to reply
No replies to this topic

#1 Health Reporter

Health Reporter

    Newsfeeder

  • RSS
  • PipPipPipPip
  • 20366 posts
  • Country:United States

Posted 20 July 2020 - 01:35 AM

Advertisement
Related Articles

In Silico Evaluation of Putative S100B Interacting Proteins in Healthy and IBD Gut Microbiota.

Cells. 2020 Jul 15;9(7):

Authors: Orsini M, Di Liddo R, Valeriani F, Mancin M, D'Incą R, Castagnetti A, Aceti A, Parnigotto PP, Romano Spica V, Michetti F

Abstract
The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusible cytokine present not only in intestinal mucosa but also in faeces. In order to identify target proteins for a putative interaction between S100B and the microbiota proteome, we developed a bioinformatics workflow by integrating the interaction features of known domains with the proteomics data derived from metataxonomic studies of the gut microbiota from healthy and inflammatory bowel disease (IBD) subjects. On the basis of the microbiota composition, proteins putatively interacting with S100B domains were in fact found, both in healthy subjects and IBD patients, in a reduced number in the latter samples, also exhibiting differences in interacting domains occurrence between the two groups. In addition, differences between ulcerative colitis and Crohn disease samples were observed. These results offer the conceptual framework for where to investigate the role of S100B as a candidate signalling molecule in the microbiota/gut communication machinery, on the basis of interactions differently conditioned by healthy or pathological microbiota.

PMID: 32679810 [PubMed - as supplied by publisher]



View the full article


Advertisement




© Copyright 1995-2014 IBD Support All rights reserved.

About Us | Contact Us | Advertise With Us | Disclaimer | Terms of Service | Crisis Resources

This website is certified by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here